ESPE Abstracts

Chronic kidney disease (CKD) is one of the most significant medical and socio-economic problems of our time.Purpose of the Research: To study the prevalence of chronic kidney disease in children and adolescents with type 1 diabetes in Uzbekistan.Materials and Methods: For conducting epidemiological studies there were examined children and adolescents of type 1 diabetes. Epidemiological data were st...

Objective: evaluate insulin resistance (IR) in children and adolescents with exogen-constitutional obesity (ECO) depending on the stage of sexual development.Materials and research methods: 100 children and adolescents with ECO of the UzBek population from 6 to 16 years were observed (mean age 11.7 ± 0.25 years). The control group consisted of 71 healthy children of the appropriate age (mean age 11.1 ± 0.33 yea...

Background: Generally, diabetic nephropathy onsets and progresses within 5–10 years after DM onset resulting in chronic kidney disease (CKD) causing death in every 4–5th patient with type I DM. Molecular-genetic studies of endogenous/genetic CKD risk factors are of high relevance in understanding of pathogenetic mechanisms underlying formation of nephrosclerosis, and in improvement of interventions.Objective and hypotheses: To assess renal func...

Aim: To identify clinical significance of enzymuria in early diagnosis of DN in children and adolescents with type 1 diabetes mellitus.Materials and methods: We examined 112 patients (47males/55 females) with type 1 diabetes mellitus. By the DN severity the patients were divided into following groups: with normoalbuminuria (NAU) (n=47), with microalbuminuria (MAU) (n=44) and with marked proteinuria (MP) (n=19). Ten healthy subj...

Objective and hypotheses: The work was initiated to assess functional condition of the kidneys and to study interrelation between ACE gene I/D polymorphism and stage of chronic kidney disease in children and adolescents with type 1 diabetes mellitus (DM) in compliance with K/DOQI recommendations (2002).Method: We examined 120 children and adolescents with type 1 DM, 53 (44.2%) males and 67 (55.8%) females among them (mean age 13.8±0.24 years. GFR wa...

Background: Because of episodic secretion of gonadotropins (LH, and FSH), basal levels of these hormones can not objectively be assessed to differentiate delayed puberty in males.Objective and hypotheses: To assess the efficacy of the GnRH agonist (as spray) in diagnosing of delayed puberty in males.Method: Prepubertal males (n=18; age range 13.3–18.5 years) were studied; buserelin 0.15 (spray) μg was administere...

Objective and hypotheses: The work was initiated to comparatively assess degree of compensation and prevalence of complications of type 1 DM in children in Uzbekistan from 1998 to 2012 according to the screening data.Method: 950 children (coverage of 80.3%) with type 1 DM were screened in 2012 within the WDF grant ‘Children’s Diabetes in Uzbekistan’, the degree of compensation and prevalence of type 1 DM chronic complications were compared...

Background: Having the onset in childhood or adolescence obesity in one third of adult people is known to progress resulting in complications. A number of studies demonstrated preservation of excessive weight in 80% of obese adolescents.Objective and Hypotheses: The work was initiated to analyze prevalence of excess body mass and obesity among children and adolescents residing in Tashkent, Uzbekistan.Method: We examined 3140 childr...

Aim: To study incidence and risk factors of diabetic nephropathy (DN) in children and adolescents as per the Republic of Uzbekistan National Register.Method: An information list (card) and appropriate software were developed on the basis of the DN register. The cards were collected in every region of Uzbekistan to be introduced into a computer database.Results: DN screening performed in children by Alikhanova N M in 1998 showed tha...

Aim: The work was initiated to study efficacy of prestarium in normoalbuminuric patients with type 1 diabetes mellitus by ACE genotype upon primary diabetic nephropathy (DN) prevention.Materials and methods: We examined normoalbuminuric 22 patients with type 1 diabetes mellitus aged from 12 to 17 years with DN duration ≧ 10 years divided into two groups by ACE polymorphism, that is, the one with II genotype (n=11) and the one with DD geno...